New Way To Treat Addiction
U.S. - Researchers from the University of Buffalo have developed a new nanoparticle that can disable a gene involved in many forms of addiction.
The team of researchers has discovered a way to "turn off" the signal sent by the brain protein DARPP-32 neurons, which indicates the drug addiction. The short interfering ribonucleic acids (siRNA), cellular components were fixed on nanoparticels of gold using nano-rods.
Modified and stabilized, these bars microscopic penetrate better into the cells. In the case of siRNA, the nano-bar may carry 40% of the acid through the blood-brain barrier, a result judged very high by the researchers. The "nano-bar complex siRNA" is able to extinguish the signal of the gene, remain stable and cross this barrier without being affected in its effectiveness.
This technique could allow the treatment of addiction. In vivo tests should be made in the hope of adding a new pharmaceutical agent to the existing arsenal in the fight against addiction. It could also be applied to Parkinson's disease, cancer and, in general, any condition requiring medication administration in the brain.
See the paper, Nanotechnology approach for drug addiction therapy: Gene silencing using delivery of gold nanorod-siRNA nanoplex in dopaminergic neurons , in the Proceedings of the National Academy of Sciences.